South San Diego is a district within San Diego, and is in the larger South Bay region of southwestern San Diego County, California. It is a practical exclave of San Diego, having no land connection with the rest of the city. It is the only part of the city which borders Mexico. South San Diego includes four of the city's official community planning areas: Otay Mesa, Otay …South San Diego is a district within San Diego, and is in the larger South Bay region of southwestern San Diego County, California. It is a practical exclave of San Diego, having no land connection with the rest of the city. It is the only part of the city which borders Mexico. South San Diego includes four of the city's official community planning areas: Otay Mesa, Otay Mesa-Nestor, San Ysidro, and the Tijuana River Valley.
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